MDH1 Antikörper (Middle Region)

Produktnummer ABIN2783317

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch MDH1 in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Rind (Kuh), Kaninchen, Pferd, Meerschweinchen, Zebrafisch (Danio rerio), Hund und Ziege und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für MDH1 Antikörper (Middle Region) (ABIN2783317)

Target: MDH1 (Malate Dehydrogenase 1, NAD (Soluble) (MDH1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Kaninchen, Pferd, Meerschweinchen, Zebrafisch (Danio rerio), Hund, Ziege

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MDH1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MDH1 Antikörper

Bindungsspezifität: Middle Region

Sequenz: NFSCLTRLDH NRAKAQIALK LGVTANDVKN VIIWGNHSST QYPDVNHAKV

Homologie: Cow: 100%, Dog: 93%, Goat: 92%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against MDH1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human MDH1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 334 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-MDH1 Antikörper (ABIN2783317)

Nussbaumer, Asara, Teplytska, Murphy, Logan, Turck, Filiou: "Selective Mitochondrial Targeting Exerts Anxiolytic Effects In Vivo." in: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Vol. 41, Issue 7, pp. 1751-8, (2016) (PubMed).

Povlsen, Løfgren, Dalgas, Birkler, Johannsen, Støttrup, Bøtker: "Protection against myocardial ischemia-reperfusion injury at onset of type 2 diabetes in Zucker diabetic fatty rats is associated with altered glucose oxidation." in: PLoS ONE, Vol. 8, Issue 5, pp. e64093, (2013) (PubMed).

Details zu MDH1

Target: MDH1 (Malate Dehydrogenase 1, NAD (Soluble) (MDH1))

Andere Bezeichnung: MDH1

Hintergrund: Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. MDH1 is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria.Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MDH-s, MDHA, MGC:1375, MOR2
Protein Interaction Partner: ISG15, UBC, NEDD8, PARK2, HSP90AB1, HSP90AA1, FUS, IQCB1, SDHA, PGM1, LDHA, ESD, Htt, PRDX5, PRDX6, SLC9A3R1, AKT1, TERF2IP, TERF1, TP53, EGFR, MPP3, MDH1, GPD1,
Protein Size: 334

Molekulargewicht: 36 kDa

Gen-ID: 4190

NCBI Accession: NM_005917, NP_005908

UniProt: P40925